Failure to detect functional neutrophil B helper cells in the human spleen.
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ABSTRACT:
SUBMITTER: Nagelkerke SQ
PROVIDER: S-EPMC3921168 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Failure to detect functional neutrophil B helper cells in the human spleen.
Nagelkerke Sietse Quirijn SQ aan de Kerk Daan Jacob DJ Jansen Machiel Hugo MH van den Berg Timo Kars TK Kuijpers Taco Willem TW
PloS one 20140211 2
A novel role for human neutrophilic granulocytes was recently described, showing that these cells, upon entering the spleen, can be reprogrammed into a distinct B cell-helper neutrophil phenotype that is capable of eliciting B cell responses such as immunoglobulin secretion, class switch recombination and somatic hypermutation. Using similar protocols, we detected a homogeneous population of CD15(high)CD16(high) neutrophils in fresh human spleen samples, which did not differ in phenotype and fun ...[more]
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