?-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia.
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ABSTRACT:
SUBMITTER: Feng X
PROVIDER: S-EPMC3921587 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia.
Feng X X Wu C-Y CY Burton F H FH Loh H H HH Wei L-N LN
Cell death and differentiation 20131025 3
Microglial activation worsens neuronal loss and contributes to progressive neurological diseases like Parkinson's disease (PD). This inflammatory progression is countered by dynorphin (Dyn), the endogenous ligand of the kappa-opioid receptor (KOR). We show that microglial β-arrestin mediates the ability of Dyn/KOR to limit endotoxin-elicited production of pro-inflammatory effectors and cytokines, subsequently protecting neurons from inflammation-induced neurotoxicity. Agonist-activated KOR enhan ...[more]
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