Ontology highlight
ABSTRACT:
SUBMITTER: Malhotra D
PROVIDER: S-EPMC3921625 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Malhotra Dheeraj D McCarthy Shane S Michaelson Jacob J JJ Vacic Vladimir V Burdick Katherine E KE Yoon Seungtai S Cichon Sven S Corvin Aiden A Gary Sydney S Gershon Elliot S ES Gill Michael M Karayiorgou Maria M Kelsoe John R JR Krastoshevsky Olga O Krause Verena V Leibenluft Ellen E Levy Deborah L DL Makarov Vladimir V Bhandari Abhishek A Malhotra Anil K AK McMahon Francis J FJ Nöthen Markus M MM Potash James B JB Rietschel Marcella M Schulze Thomas G TG Sebat Jonathan J
Neuron 20111201 6
While it is known that rare copy-number variants (CNVs) contribute to risk for some neuropsychiatric disorders, the role of CNVs in bipolar disorder is unclear. Here, we reasoned that a contribution of CNVs to mood disorders might be most evident for de novo mutations. We performed a genome-wide analysis of de novo CNVs in a cohort of 788 trios. Diagnoses of offspring included bipolar disorder (n = 185), schizophrenia (n = 177), and healthy controls (n = 426). Frequencies of de novo CNVs were si ...[more]