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PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.

ABSTRACT: Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Repeated infections with C. trachomatis lead to serious sequelae, such as infertility. It is unclear why the adaptive immune system, specifically the CD8(+) T cell response, is unable to protect against subsequent C. trachomatis infections. In this article, we characterize the mucosal CD8(+) T cell response to C. trachomatis in the murine genital tract. We demonstrate that the immunoinhibitory ligand, PD-L1, contributes to the defective CD8(+) T cell response. Deletion or inhibition of PD-L1 restores the CD8(+) T cell response and enhances C. trachomatis clearance.

SUBMITTER: Fankhauser SC

PROVIDER: S-EPMC3921669 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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PD-L1 limits the mucosal CD8+ T cell response to Chlamydia trachomatis.

Fankhauser Sarah C SC Starnbach Michael N MN

Journal of immunology (Baltimore, Md. : 1950) 20131218 3

Chlamydia trachomatis infection is the most common bacterial sexually transmitted disease in the United States. Repeated infections with C. trachomatis lead to serious sequelae, such as infertility. It is unclear why the adaptive immune system, specifically the CD8(+) T cell response, is unable to protect against subsequent C. trachomatis infections. In this article, we characterize the mucosal CD8(+) T cell response to C. trachomatis in the murine genital tract. We demonstrate that the immunoin ...[more]

PMID: 24353266

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