Ontology highlight
ABSTRACT:
SUBMITTER: Zucchelli M
PROVIDER: S-EPMC3922294 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Zucchelli Marco M Camilleri Michael M Andreasson Anna Nixon AN Bresso Francesca F Dlugosz Aldona A Halfvarson Jonas J Törkvist Leif L Schmidt Peter T PT Karling Pontus P Ohlsson Bodil B Duerr Richard H RH Simren Magnus M Lindberg Greger G Agreus Lars L Carlson Paula P Zinsmeister Alan R AR D'Amato Mauro M
Gut 20110602 12
<h4>Background</h4>Irritable bowel syndrome (IBS) is the most common gastrointestinal disorder, affecting more than 10% of the general population worldwide. Although a genetic component is suspected, unambiguous susceptibility genes have so far not been identified. This study tested the hypothesis that genes contributing to epithelial barrier integrity, control of mucosal immune responses and interactions with bacteria in the gut are associated with IBS.<h4>Methods</h4>Single nucleotide polymorp ...[more]