Accounting for population variation in targeted proteomics.
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ABSTRACT:
SUBMITTER: Fujimoto GM
PROVIDER: S-EPMC3923399 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Publications
Accounting for population variation in targeted proteomics.
Fujimoto Grant M GM Monroe Matthew E ME Rodriguez Larissa L Wu Chaochao C MacLean Brendan B Smith Richard D RD MacCoss Michael J MJ Payne Samuel H SH
Journal of proteome research 20131216 1
Individual proteomes typically differ from the reference human proteome at ∼10,000 single amino acid variants. When viewed on the population scale, this individual variation results in a wide variety of protein sequences. In targeted proteomics experiments, such variability can confound accurate protein quantification. To assist researchers in identifying target peptides with high variability within the human population, we have created the Population Variation plug-in for Skyline, which provide ...[more]
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