Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.
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ABSTRACT:
SUBMITTER: Palmenberg AC
PROVIDER: S-EPMC3923423 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Publications
Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.
Palmenberg Ann C AC Spiro David D Kuzmickas Ryan R Wang Shiliang S Djikeng Appolinaire A Rathe Jennifer A JA Fraser-Liggett Claire M CM Liggett Stephen B SB
Science (New York, N.Y.) 20090212 5923
Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific diversity, including a potential newly identified species (HRV-D); mutations in field ...[more]
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