Biomarker selection for medical diagnosis using the partial area under the ROC curve.
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ABSTRACT:
SUBMITTER: Hsu MJ
PROVIDER: S-EPMC3923449 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Biomarker selection for medical diagnosis using the partial area under the ROC curve.
Hsu Man-Jen MJ Chang Yuan-Chin Ivan YC Hsueh Huey-Miin HM
BMC research notes 20140110
<h4>Background</h4>A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding an ideal biomarker is not easy and combining multiple biomarkers provides a promising alternative. Moreover, some biomarkers based on the optimal linear combination do not have enough discriminatory power. As a result, the aim of this study was to find the significant biomarkers based on the optimal linear combination maximizing the pAUC for assessment of the biomarkers.<h4>Methods</h4> ...[more]
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