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DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra.


ABSTRACT: De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, their adoption threshold remains quite high. We here present a user-friendly and lightweight graphical user interface called DeNovoGUI for running parallelized versions of the freely available de novo sequencing software PepNovo+, greatly simplifying the use of de novo sequencing in proteomics. Our platform-independent software is freely available under the permissible Apache2 open source license. Source code, binaries, and additional documentation are available at http://denovogui.googlecode.com .

SUBMITTER: Muth T 

PROVIDER: S-EPMC3923451 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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DeNovoGUI: an open source graphical user interface for de novo sequencing of tandem mass spectra.

Muth Thilo T   Weilnböck Lisa L   Rapp Erdmann E   Huber Christian G CG   Martens Lennart L   Vaudel Marc M   Barsnes Harald H  

Journal of proteome research 20140107 2


De novo sequencing is a popular technique in proteomics for identifying peptides from tandem mass spectra without having to rely on a protein sequence database. Despite the strong potential of de novo sequencing algorithms, their adoption threshold remains quite high. We here present a user-friendly and lightweight graphical user interface called DeNovoGUI for running parallelized versions of the freely available de novo sequencing software PepNovo+, greatly simplifying the use of de novo sequen  ...[more]

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