Ontology highlight
ABSTRACT:
SUBMITTER: Jabbour E
PROVIDER: S-EPMC3923606 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Jabbour Elias E Takahashi Koichi K Wang Xuemei X Cornelison A Megan AM Abruzzo Lynne L Kadia Tapan T Borthakur Gautam G Estrov Zeev Z O'Brien Susan S Mallo Mar M Wierda William W Pierce Sherry S Wei Yue Y Sole Francisco F Chen Rui R Kantarjian Hagop H Garcia-Manero Guillermo G
American journal of hematology 20130723 10
We hypothesized that the dynamic acquisition of cytogenetic abnormalities (ACA) during the follow up of myelodysplastic syndromes (MDS) could be associated with poor prognosis. We conducted a retrospective analysis of 365 patients with IPSS low or intermediate-1 risk MDS who had at least two consecutive cytogenetic analyses during the follow up. Acquisition of cytogenetic abnormalities was detected in 107 patients (29%). The most frequent alteration involved chromosome 7 in 21% of ACA cases. Med ...[more]