Ontology highlight
ABSTRACT:
SUBMITTER: Fritz JM
PROVIDER: S-EPMC3923636 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Fritz Jill M JM Dong Mei M Apsley Karen S KS Martin Emily P EP Na Cheng-Lun CL Sitaraman Sneha S Weaver Timothy E TE
Molecular biology of the cell 20131211 4
Endoplasmic reticulum-localized DnaJ 4 (ERdj4) is an immunoglobulin-binding protein (BiP) cochaperone and component of the endoplasmic reticulum-associated degradation (ERAD) pathway that functions to remove unfolded/misfolded substrates from the ER lumen under conditions of ER stress. To elucidate the function of ERdj4 in vivo, we disrupted the ERdj4 locus using gene trap (GT) mutagenesis, leading to hypomorphic expression of ERdj4 in mice homozygous for the trapped allele (ERdj4(GT/GT)). Appro ...[more]