Ontology highlight
ABSTRACT:
SUBMITTER: Lv C
PROVIDER: S-EPMC3923795 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Lv Cheng C Li Xiaoguang X Li Fangting F Li Tiejun T
PloS one 20140213 2
Genetic switching driven by noise is a fundamental cellular process in genetic regulatory networks. Quantitatively characterizing this switching and its fluctuation properties is a key problem in computational biology. With an autoregulatory dimer model as a specific example, we design a general methodology to quantitatively understand the metastability of gene regulatory system perturbed by intrinsic noise. Based on the large deviation theory, we develop new analytical techniques to describe an ...[more]