Ontology highlight
ABSTRACT:
SUBMITTER: Jahromi AH
PROVIDER: S-EPMC3925341 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Jahromi Amin Haghighat AH Fu Yuan Y Miller Kali A KA Nguyen Lien L Luu Long M LM Baranger Anne M AM Zimmerman Steven C SC
Journal of medicinal chemistry 20131121 23
An expanded CUG repeat transcript (CUG(exp)) is the causative agent of myotonic dystrophy type 1 (DM1) by sequestering muscleblind-like 1 protein (MBNL1), a regulator of alternative splicing. On the basis of a ligand (1) that was previously reported to be active in an in vitro assay, we present the synthesis of a small library containing 10 dimeric ligands (4-13) that differ in length, composition, and attachment point of the linking chain. The oligoamino linkers gave a greater gain in affinity ...[more]