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Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.


ABSTRACT:

Importance

Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable.

Objective

To develop a measure of grammatical comprehension and examine this comparatively in PPA variants and behavioural-variant frontotemporal degeneration (bvFTD) and to assess the neuroanatomic basis for these deficits with volumetric grey matter atrophy and whole-brain fractional anisotropy (FA) in white matter tracts.

Design

Case-control study.

Setting

Academic medical centre.

Participants

39 patients with variants of PPA (naPPA=12, lvPPA=15 and svPPA=12), 27 bvFTD patients without aphasia and 12 healthy controls.

Main outcome measure

Grammatical comprehension accuracy.

Results

Patients with naPPA had selective difficulty understanding cleft sentence structures, while all PPA variants and patients with bvFTD were impaired with sentences containing a centre-embedded subordinate clause. Patients with bvFTD were also impaired understanding sentences involving short-term memory. Linear regressions related grammatical comprehension difficulty in naPPA to left anterior-superior temporal atrophy and reduced FA in corpus callosum and inferior frontal-occipital fasciculus. Difficulty with centre-embedded sentences in other PPA variants was related to other brain regions.

Conclusions and relevance

These findings emphasise a distinct grammatical comprehension deficit in naPPA and associate this with interruption of a frontal-temporal neural network.

SUBMITTER: Charles D 

PROVIDER: S-EPMC3925677 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Publications

Grammatical comprehension deficits in non-fluent/agrammatic primary progressive aphasia.

Charles Dorothy D   Olm Christopher C   Powers John J   Ash Sharon S   Irwin David J DJ   McMillan Corey T CT   Rascovsky Katya K   Grossman Murray M  

Journal of neurology, neurosurgery, and psychiatry 20130913 3


<h4>Importance</h4>Grammatical comprehension difficulty is an essential supporting feature of the non-fluent/agrammatic variant of primary progressive aphasia (naPPA), but well-controlled clinical measures of grammatical comprehension are unavailable.<h4>Objective</h4>To develop a measure of grammatical comprehension and examine this comparatively in PPA variants and behavioural-variant frontotemporal degeneration (bvFTD) and to assess the neuroanatomic basis for these deficits with volumetric g  ...[more]

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