Ontology highlight
ABSTRACT:
SUBMITTER: Kohrt D
PROVIDER: S-EPMC3925736 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kohrt Dawn D Crary Jennifer J Zimmer Marc M Patrick Aaron N AN Ford Heide L HL Hinds Philip W PW Grossel Martha J MJ
Cell cycle (Georgetown, Tex.) 20131012 1
Cyclin-dependent kinase 6 (Cdk6) is a D-Cyclin-activated kinase that is directly involved in driving the cell cycle through inactivation of pRB in G₁ phase. Increasingly, evidence suggests that CDK6, while directly driving the cell cycle, may only be essential for proliferation of specialized cell types, agreeing with the notion that CDK6 also plays an important role in differentiation. Here, evidence is presented that CDK6 binds to and promotes degradation of the EYA2 protein. The EYA proteins ...[more]