Ontology highlight
ABSTRACT:
SUBMITTER: Toepke MW
PROVIDER: S-EPMC3925890 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Toepke Michael W MW Impellitteri Nicholas A NA Lan Levengood Sheeny K SK Boeldt Derek S DS Bird Ian M IM Murphy William L WL
Advanced healthcare materials 20120511 4
VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle. ...[more]