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Regulating specific growth factor signaling using immobilized branched ligands.

ABSTRACT: VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.

SUBMITTER: Toepke MW

PROVIDER: S-EPMC3925890 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Regulating specific growth factor signaling using immobilized branched ligands.

Toepke Michael W MW Impellitteri Nicholas A NA Lan Levengood Sheeny K SK Boeldt Derek S DS Bird Ian M IM Murphy William L WL

Advanced healthcare materials 20120511 4

VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle. ...[more]

PMID: 23184776

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