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Regulating specific growth factor signaling using immobilized branched ligands.


ABSTRACT: VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle.

SUBMITTER: Toepke MW 

PROVIDER: S-EPMC3925890 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature

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Regulating specific growth factor signaling using immobilized branched ligands.

Toepke Michael W MW   Impellitteri Nicholas A NA   Lan Levengood Sheeny K SK   Boeldt Derek S DS   Bird Ian M IM   Murphy William L WL  

Advanced healthcare materials 20120511 4


VEGF-binding peptide ligands are incorporated into hydrogel microspheres and reduce the amount of growth factor in solution. VEGF binding affinity is enhanced by creating ligands with a dimer structure. The spheres are able to knock down VEGF-mediated HUVEC growth and reduce calcium signaling. The binding interaction is reversible, allowing the spheres to be used as a VEGF delivery vehicle. ...[more]

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