Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC3925907 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Li Zhaoming Z Tian Tian T Hu Xiaopeng X Zhang Xudong X Li Lifeng L Nan Feifei F Chang Yu Y Wang Xinhua X Sun Zhenchang Z Lv Feng F Zhang Mingzhi M
International journal of clinical and experimental pathology 20140115 2
The Six1 homeodomain protein is a developmental transcription factor that has been implicated in tumor onset and progression. Recently, it's reported that overexpression of Six1 is sufficient to induce epithelial-to-mesenchymal transition (EMT) and metastasis of colorectal cancer. Moreover, its expression is significantly associated with poorer overall survival probability in advanced-stage colorectal cancer. To address whether Six1 could serve as a therapeutic target for human colorectal cancer ...[more]