Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC3925968 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wang Yong Y Liu Yanxin Y Deberg Hannah A HA Nomura Takeshi T Hoffman Melinda Tonks MT Rohde Paul R PR Schulten Klaus K Martinac Boris B Selvin Paul R PR
eLife 20140218
The mechanosensitive channel of large conductance, which serves as a model system for mechanosensitive channels, has previously been crystallized in the closed form, but not in the open form. Ensemble measurements and electrophysiological sieving experiments show that the open-diameter of the channel pore is >25 Å, but the exact size and whether the conformational change follows a helix-tilt or barrel-stave model are unclear. Here we report measurements of the distance changes on liposome-recons ...[more]