Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC3926035 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Yang Yunfan Y Liu Min M Li Dengwen D Ran Jie J Gao Jinmin J Suo Shaojun S Sun Shao-Cong SC Zhou Jun J
Proceedings of the National Academy of Sciences of the United States of America 20140127 6
Oriented cell division is critical for cell fate specification, tissue organization, and tissue homeostasis, and relies on proper orientation of the mitotic spindle. The molecular mechanisms underlying the regulation of spindle orientation remain largely unknown. Herein, we identify a critical role for cylindromatosis (CYLD), a deubiquitinase and regulator of microtubule dynamics, in the control of spindle orientation. CYLD is highly expressed in mitosis and promotes spindle orientation by stabi ...[more]