Ontology highlight
ABSTRACT:
SUBMITTER: Kanarek N
PROVIDER: S-EPMC3926043 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kanarek Naama N Grivennikov Sergei I SI Leshets Michael M Lasry Audrey A Alkalay Irit I Horwitz Elad E Shaul Yoav D YD Stachler Matthew M Voronov Elena E Apte Ron N RN Pagano Michele M Pikarsky Eli E Karin Michael M Ghosh Sankar S Ben-Neriah Yinon Y
Proceedings of the National Academy of Sciences of the United States of America 20140127 6
β-TrCP, the substrate recognition subunit of SCF-type ubiquitin ligases, is ubiquitously expressed from two distinct paralogs, targeting for degradation many regulatory proteins, among which is the NF-κB inhibitor IκB. To appreciate tissue-specific roles of β-TrCP, we studied the consequences of inducible ablation of three or all four alleles of the E3 in the mouse gut. The ablation resulted in mucositis, a destructive gut mucosal inflammation, which is a common complication of different cancer ...[more]