Ontology highlight
ABSTRACT:
SUBMITTER: Lavinder JJ
PROVIDER: S-EPMC3926051 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Lavinder Jason J JJ Wine Yariv Y Giesecke Claudia C Ippolito Gregory C GC Horton Andrew P AP Lungu Oana I OI Hoi Kam Hon KH DeKosky Brandon J BJ Murrin Ellen M EM Wirth Megan M MM Ellington Andrew D AD Dörner Thomas T Marcotte Edward M EM Boutz Daniel R DR Georgiou George G
Proceedings of the National Academy of Sciences of the United States of America 20140127 6
Most vaccines confer protection via the elicitation of serum antibodies, yet more than 100 y after the discovery of antibodies, the molecular composition of the human serum antibody repertoire to an antigen remains unknown. Using high-resolution liquid chromatography tandem MS proteomic analyses of serum antibodies coupled with next-generation sequencing of the V gene repertoire in peripheral B cells, we have delineated the human serum IgG and B-cell receptor repertoires following tetanus toxoid ...[more]