Ontology highlight
ABSTRACT:
SUBMITTER: Gaedicke S
PROVIDER: S-EPMC3926065 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Gaedicke Simone S Braun Friederike F Prasad Shruthi S Machein Marcia M Firat Elke E Hettich Michael M Gudihal Ravindra R Zhu Xuekai X Klingner Kerstin K Schüler Julia J Herold-Mende Christel C CC Grosu Anca-Ligia AL Behe Martin M Weber Wolfgang W Mäcke Helmut H Niedermann Gabriele G
Proceedings of the National Academy of Sciences of the United States of America 20140127 6
A technology that visualizes tumor stem cells with clinically relevant tracers could have a broad impact on cancer diagnosis and treatment. The AC133 epitope of CD133 currently is one of the best-characterized tumor stem cell markers for many intra- and extracranial tumor entities. Here we demonstrate the successful noninvasive detection of AC133(+) tumor stem cells by PET and near-infrared fluorescence molecular tomography in subcutaneous and orthotopic glioma xenografts using antibody-based tr ...[more]