Ontology highlight
ABSTRACT:
SUBMITTER: Fletcher CV
PROVIDER: S-EPMC3926074 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Fletcher Courtney V CV Staskus Kathryn K Wietgrefe Stephen W SW Rothenberger Meghan M Reilly Cavan C Chipman Jeffrey G JG Beilman Greg J GJ Khoruts Alexander A Thorkelson Ann A Schmidt Thomas E TE Anderson Jodi J Perkey Katherine K Stevenson Mario M Perelson Alan S AS Douek Daniel C DC Haase Ashley T AT Schacker Timothy W TW
Proceedings of the National Academy of Sciences of the United States of America 20140127 6
Antiretroviral therapy can reduce HIV-1 to undetectable levels in peripheral blood, but the effectiveness of treatment in suppressing replication in lymphoid tissue reservoirs has not been determined. Here we show in lymph node samples obtained before and during 6 mo of treatment that the tissue concentrations of five of the most frequently used antiretroviral drugs are much lower than in peripheral blood. These lower concentrations correlated with continued virus replication measured by the slo ...[more]