Ontology highlight
ABSTRACT:
SUBMITTER: Bellera CL
PROVIDER: S-EPMC3926237 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Bellera Carolina L CL Balcazar Darío E DE Alberca Lucas L Labriola Carlos A CA Talevi Alan A Carrillo Carolina C
TheScientificWorldJournal 20140130
Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank database, which compiles FDA-approved and investigational drugs. 54 approved drugs were selected as candidates, 3 of which were acquired and tested on Cz and T. cruzi epimastigotes proliferation. Amon ...[more]