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Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.

ABSTRACT: Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology.

SUBMITTER: Parisi-Amon A 

PROVIDER: S-EPMC3926432 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Protein-engineered injectable hydrogel to improve retention of transplanted adipose-derived stem cells.

Parisi-Amon Andreina A   Mulyasasmita Widya W   Chung Cindy C   Heilshorn Sarah C SC  

Advanced healthcare materials 20120928 3

Improved retention of transplanted stem cells is achieved through minimally invasive delivery in MITCH, a mixing-induced two-component hydrogel that was engineered to possess shear-thinning and self-healing thixotropic properties. MITCH, an ideal injectable cell-delivery vehicle, supports 3D stem-cell culture, resulting in high cell viability and physiologically relevant cell morphology. ...[more]

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