Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.
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ABSTRACT:
SUBMITTER: Akfirat C
PROVIDER: S-EPMC3926514 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Tumour cell survival mechanisms in lethal metastatic prostate cancer differ between bone and soft tissue metastases.
Akfirat Canan C Zhang Xiaotun X Ventura Aviva A Berel Dror D Colangelo Mary E ME Miranti Cindy K CK Krajewska Maryla M Reed John C JC Higano Celestia S CS True Lawrence D LD Vessella Robert L RL Morrissey Colm C Knudsen Beatrice S BS
The Journal of pathology 20130701 3
The complexity of survival mechanisms in cancer cells from patients remains poorly understood. To obtain a comprehensive picture of tumour cell survival in lethal prostate cancer metastases, we examined five survival proteins that operate within three survival pathways in a cohort of 185 lethal metastatic prostate metastases obtained from 44 patients. The expression levels of BCL-2, BCL-XL, MCL-1, cytoplasmic survivin, nuclear survivin, and stathmin were measured by immunohistochemistry in a tis ...[more]
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