Ontology highlight
ABSTRACT:
SUBMITTER: Belushkin AA
PROVIDER: S-EPMC3926948 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Belushkin Alexander A AA Vinogradov Dmitry V DV Gelfand Mikhail S MS Osterman Andrei L AL Cieplak Piotr P Kazanov Marat D MD
Proteomics 20131211 1
Proteolytic signaling, or regulated proteolysis, is an essential part of many important pathways such as Notch, Wnt, and Hedgehog. How the structure of the cleaved substrate regions influences the efficacy of proteolytic processing remains underexplored. Here, we analyzed the relative importance in proteolysis of various structural features derived from substrate sequences using a dataset of more than 5000 experimentally verified proteolytic events captured in CutDB. Accessibility to the solvent ...[more]