Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC3927138 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Yuan Yuan Y Hartland Kate K Boskovic Zarko Z Wang Yikai Y Walpita Deepika D Lysy Philippe A PA Zhong Cheng C Young Damian W DW Kim Young-Kwon YK Tolliday Nicola J NJ Sokal Etienne M EM Schreiber Stuart L SL Wagner Bridget K BK
Chemistry & biology 20131127 12
Pancreatic and duodenal homeobox 1 (PDX1), a member of the homeodomain-containing transcription factor family, is a key transcription factor important for both pancreas development and mature β cell function. The ectopic overexpression of Pdx1, Neurog3, and MafA in mice reprograms acinar cells to insulin-producing cells. We developed a quantitative PCR-based gene expression assay to screen more than 60,000 compounds for expression of each of these genes in the human PANC-1 ductal carcinoma cell ...[more]