Ontology highlight
ABSTRACT:
SUBMITTER: Le TB
PROVIDER: S-EPMC3927313 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Le Tung B K TB Imakaev Maxim V MV Mirny Leonid A LA Laub Michael T MT
Science (New York, N.Y.) 20131024 6159
Chromosomes must be highly compacted and organized within cells, but how this is achieved in vivo remains poorly understood. We report the use of chromosome conformation capture coupled with deep sequencing (Hi-C) to map the structure of bacterial chromosomes. Analysis of Hi-C data and polymer modeling indicates that the Caulobacter crescentus chromosome consists of multiple, largely independent spatial domains that are probably composed of supercoiled plectonemes arrayed into a bottle brush-lik ...[more]