Dose response to vitamin D supplementation in African Americans: results of a 4-arm, randomized, placebo-controlled trial.

ABSTRACT:

Background

Association studies have suggested that lower circulating 25-hydroxyvitamin D [25(OH)D] in African Americans may partially underlie higher rates of cardiovascular disease and cancer in this population. Nonetheless, the relation between vitamin D supplementation and 25(OH)D concentrations in African Americans remains undefined.

Objective

Our primary objective was to determine the dose-response relation between vitamin D and plasma 25(OH)D.

Design

A total of 328 African Americans in Boston, MA, were enrolled over 3 winters from 2007 to 2010 and randomly assigned to receive a placebo or 1000, 2000, or 4000 IU vitamin D₃/d for 3 mo. Subjects completed sociodemographic and dietary questionnaires, and plasma samples were drawn at baseline and 3 and 6 mo.

Resul

SUBMITTER: Ng K 

PROVIDER: S-EPMC3927692 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature