Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys.
Ontology highlight
ABSTRACT:
SUBMITTER: Fanucchi MV
PROVIDER: S-EPMC3927836 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
Publications
Immunostimulatory oligonucleotides attenuate airways remodeling in allergic monkeys.
Fanucchi Michelle V MV Schelegle Edward S ES Baker Gregory L GL Evans Michael J MJ McDonald Ruth J RJ Gershwin Laurel J LJ Raz Eyal E Hyde Dallas M DM Plopper Charles G CG Miller Lisa A LA
American journal of respiratory and critical care medicine 20040811 11
To determine whether inhaled immunostimulatory DNA sequence oligonucleotides containing CpG motifs mitigate the pathophysiologic manifestation of the asthmatic phenotype (airways hyperresponsiveness and airways remodeling), rhesus monkeys with experimentally induced allergic airways disease were treated seven times with inhaled immunostimulatory oligonucleotides (or sham) periodically for 33 weeks. Airways hyperresponsiveness was reduced twofold in immunostimulatory DNA sequence-treated compared ...[more]
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