HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways.
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ABSTRACT:
SUBMITTER: Kim SH
PROVIDER: S-EPMC3928010 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Publications
HIG2 promotes colorectal cancer progression via hypoxia-dependent and independent pathways.
Kim Sun-Hee SH Wang Dingzhi D Park Yun-Yong YY Katoh Hiroshi H Margalit Ofer O Sheffer Michal M Wu Hong H Holla Vijaykumar R VR Lee Ju-Seog JS DuBois Raymond N RN
Cancer letters 20130802 2
HIG2 (hypoxia-inducible gene 2) is a biomarker of hypoxia and elevated in several cancers. Here, we show that HIG2 also upregulated HIF-1α expression under hypoxic conditions and enhanced AP-1 expression under normoxic conditions, which affects colorectal cancer cell survival. Importantly, over-expression of HIG2 promoted tumor growth by suppressing apoptosis in a mouse orthotopic model. These results are likely relevant to human disease since we found that the expression of HIG2 is gradually el ...[more]
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