Inhibition of SATB1 by shRNA suppresses the proliferation of cutaneous malignant melanoma.
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ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC3929234 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Inhibition of SATB1 by shRNA suppresses the proliferation of cutaneous malignant melanoma.
Zhang Lei L Cheng Fang F He Runzhi R Chen Hao H Liu Yi Y Sun Jianfang J
Cancer biotherapy & radiopharmaceuticals 20140107 2
Overexpression of special AT-rich sequence binding protein 1 (SATB1), a global genome organizer, as a predictor of poor prognosis in cutaneous malignant melanoma (CMM) attracted great interest in previous research. In this article, upregulated SATB1 was observed in three melanoma cell lines and in eight CMM tissues. After downregulating SATB1 by RNAi, proliferation of A375 was suppressed in vitro and in vivo. In summary, the proliferation of CMM could be related closely to the SATB1 gene. Interf ...[more]
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