Ontology highlight
ABSTRACT:
SUBMITTER: Martin HL
PROVIDER: S-EPMC3929252 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Breast cancer (Dove Medical Press) 20140110
Breast cancer is the most common cancer in women worldwide, and resistance to the current therapeutics, often concurrently, is an increasing clinical challenge. By understanding the molecular mechanisms behind multidrug-resistant breast cancer, new treatments may be developed. Here we review the recent advances in this understanding, emphasizing the common mechanisms underlying resistance to both targeted therapies, notably tamoxifen and trastuzumab, and traditional chemotherapies. We focus prim ...[more]