Unknown

Dataset Information

0

Immunovirotherapy for the treatment of glioblastoma.


ABSTRACT: We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47?-IL12.

SUBMITTER: Cheema TA 

PROVIDER: S-EPMC3929360 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immunovirotherapy for the treatment of glioblastoma.

Cheema Tooba A TA   Fecci Peter E PE   Ning Jianfang J   Rabkin Samuel D SD  

Oncoimmunology 20140101 1


We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47∆-IL12. ...[more]

Similar Datasets

| S-EPMC7252967 | biostudies-literature
| S-EPMC6037044 | biostudies-literature
| S-EPMC8473045 | biostudies-literature
2019-07-24 | BIOMD0000000757 | BioModels
| S-EPMC7664223 | biostudies-literature
| S-EPMC3883781 | biostudies-literature