Drugs derived from phage display: from candidate identification to clinical practice.
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ABSTRACT:
SUBMITTER: Nixon AE
PROVIDER: S-EPMC3929457 | biostudies-literature | 2014 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Drugs derived from phage display: from candidate identification to clinical practice.
Nixon Andrew E AE Sexton Daniel J DJ Sexton Daniel J DJ Ladner Robert C RC
mAbs 20140101 1
Phage display, one of today’s fundamental drug discovery technologies, allows identification of a broad range of biological drugs, including peptides, antibodies and other proteins, with the ability to tailor critical characteristics such as potency, specificity and cross-species binding. Further, unlike in vivo technologies, generating phage display-derived antibodies is not restricted by immunological tolerance. Although more than 20 phage display-derived antibody and peptides are currently in ...[more]
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