Atrial natriuretic peptide and type 2 diabetes development--biomarker and genotype association study.

ABSTRACT:

Background

We have recently shown that low plasma levels of mid-regional atrial natriuretic peptide (MR-ANP) predict development of diabetes and glucose progression over time, independently of known risk factors for diabetes development. However, since MR-ANP levels might be influenced by unknown factors causing diabetes, we cannot rule out that such relationship might be confounded. Previous studies have shown an association of a single nucleotide polymorphism rs5068 on the natriuretic peptide precursor A (NPPA) locus gene with higher levels of circulating ANP. Since gene variants are inherited randomly and not subject to confounding, we aimed to investigate whether the variant rs5068 within the NPPA locus is associated with incident type 2 diabetes.

Methods

We genotyped th

SUBMITTER: Jujic A 

PROVIDER: S-EPMC3929630 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature