Ontology highlight
ABSTRACT:
SUBMITTER: Esteva-Font C
PROVIDER: S-EPMC3929666 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Esteva-Font Cristina C Jin Byung-Ju BJ Verkman A S AS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20131212 3
Aquaporin 1 (AQP1) is a plasma membrane water-transporting protein expressed strongly in tumor microvascular endothelia. We previously reported impaired angiogenesis in implanted tumors in AQP1-deficient mice and reduced migration of AQP1-deficient endothelial cells in vitro. Here, we investigated the consequences of AQP1 deficiency in mice that spontaneously develop well-differentiated, luminal-type breast adenomas with lung metastases [mouse mammary tumor virus-driven polyoma virus middle T on ...[more]