KCNQ1 rs2237892 C?T gene polymorphism and type 2 diabetes mellitus in the Asian population: a meta-analysis of 15,736 patients.

ABSTRACT: The KCNQ1 rs2237892 C?T gene polymorphism is reportedly associated with T2DM susceptibility, but various studies show conflicting results. To explore this association in the Asian population, a meta-analysis of 15,736 patients from 10 individual studies was performed. The pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were evaluated using random-effect or fixed-effect models. A significant relationship between the KCNQ1 rs2237892 C?T gene polymorphism and T2DM was observed in the Asian population under the allelic (OR, 1.350; 95% CI, 1.240-1.480; P < 0.00001), recessive (OR: 0.650; 95% CI: 0.570-0.730; P < 0.00001), dominant (OR: 1.450; 95% CI: 1.286-1.634; P < 0.00001), and additive (OR: 1.346; 95% CI: 1.275-1.422; P < 0.00001) genetic models. In the subgroup analysis by race, a significant association was found in Chinese, Korean and Malaysia population, but not in Indian population. KCNQ1 rs2237892 C?T gene polymorphism was found to be significantly associated with increased T2DM risk in the Asian population, except Indian population. The C allele of the KCNQ1 rs2237892 C?T gene polymorphism may confer susceptibility to T2DM.

SUBMITTER: Li YY 

PROVIDER: S-EPMC3930414 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature