Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC3930416 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wu Chongming C Guo Yanshen Y Su Yan Y Zhang Xue X Luan Hong H Zhang Xiaopo X Zhu Huixin H He Huixia H Wang Xiaoliang X Sun Guibo G Sun Xiaobo X Guo Peng P Zhu Ping P
Journal of cellular and molecular medicine 20131128 2
Cordycepin is a bioactive component of the fungus Cordyceps militaris. Previously, we showed that cordycepin can alleviate hyperlipidemia through enhancing the phosphorylation of AMP-activated protein kinase (AMPK), but the mechanism of this stimulation is unknown. Here, we investigated the potential mechanisms of cordycepin-induced AMPK activation in HepG2 cells. Treatment with cordycepin largely reduced oleic acid (OA)-elicited intracellular lipid accumulation and increased AMPK activity in a ...[more]