Ontology highlight
ABSTRACT:
SUBMITTER: Borrell-Pages M
PROVIDER: S-EPMC3930418 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Borrell-Pagès Maria M Romero July Carolina JC Badimon Lina L
Journal of cellular and molecular medicine 20131125 2
Molecular changes involved in cell differentiation are only partially known. Circulating inflammatory cells need to differentiate to perform specialized functions in target tissues. Here, we hypothesized that low-density lipoprotein receptor-related protein 5 (LRP5) is involved, through its participation in the canonical Wnt/β-catenin signalling, in the differentiation process of monocytic cells. To this aim, we characterized differentiation mechanisms of HL60 cells and primary human monocytes. ...[more]