Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC3930729 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Guo Yugang Y Li Rui R Song Xiaoping X Zhong Yongjun Y Wang Chenguang C Jia Hao H Wu Lidan L Wang Dong D Fang Fang F Ma Jiajia J Kang Wenyao W Sun Jie J Tian Zhigang Z Xiao Weihua W
PloS one 20140220 2
CD83 is a highly glycosylated type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily. CD83 is upregulated during dendritic cell (DC) maturation, which is critical for the initiation of adaptive immune responses. The soluble isoform of CD83 (sCD83) is encoded by alternative splicing from full-length CD83 mRNA and inhibits DC maturation, which suggests that sCD83 acts as a potential immune suppressor. In this study, we developed a sound strategy to express functional sCD8 ...[more]