Ontology highlight
ABSTRACT:
SUBMITTER: Peterson SE
PROVIDER: S-EPMC3931019 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Peterson Suzanne E SE Loring Jeanne F JF
The Journal of biological chemistry 20131220 8
Human pluripotent stem cells (hPSCs) are known to acquire genomic changes as they proliferate and differentiate. Despite concerns that these changes will compromise the safety of hPSC-derived cell therapy, there is currently scant evidence linking the known hPSC genomic abnormalities with malignancy. For the successful use of hPSCs for clinical applications, we will need to learn to distinguish between innocuous genomic aberrations and those that may cause tumors. To minimize any effects of acqu ...[more]