Ontology highlight
ABSTRACT:
SUBMITTER: Annayev Y
PROVIDER: S-EPMC3931061 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Annayev Yunus Y Adar Sheera S Chiou Yi-Ying YY Lieb Jason D JD Sancar Aziz A Ye Rui R
The Journal of biological chemistry 20140102 8
The mammalian circadian clock is a molecular oscillator composed of a feedback loop that involves transcriptional activators CLOCK and BMAL1, and repressors Cryptochrome (CRY) and Period (PER). Here we show that a direct CLOCK·BMAL1 target gene, Gm129, is a novel regulator of the feedback loop. ChIP analysis revealed that the CLOCK·BMAL1·CRY1 complex strongly occupies the promoter region of Gm129. Both mRNA and protein levels of GM129 exhibit high amplitude circadian oscillations in mouse liver, ...[more]