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4-Quinolone alkaloids from Melochia odorata.

ABSTRACT: The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 ?M and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 ?M, respectively. The structures of the alkaloids were established by spectroscopic data interpretation.

SUBMITTER: Jadulco RC

PROVIDER: S-EPMC3931125 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature

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4-Quinolone alkaloids from Melochia odorata.

Jadulco Raquel C RC Pond Christopher D CD Van Wagoner Ryan M RM Koch Michael M Gideon Osia G OG Matainaho Teatulohi K TK Piskaut Pius P Barrows Louis R LR

Journal of natural products 20140107 1

The methanol extract of Melochia odorata yielded three 4-quinolone alkaloids including waltherione A (1) and two new alkaloids, waltherione C (2) and waltherione D (3). Waltheriones A and C showed significant activities in an in vitro anti-HIV cytoprotection assay at concentrations of 56.2 and 0.84 μM and inhibition of HIV P24 formation of more than 50% at 1.7 and 0.95 μM, respectively. The structures of the alkaloids were established by spectroscopic data interpretation. ...[more]

PMID: 24392742

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4-Quinolone alkaloids from Melochia odorata.

Publications

4-Quinolone alkaloids from Melochia odorata.

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