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Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes.


ABSTRACT: Exenatide treatment improves glycemia in adults with type 2 diabetes and has been shown to reduce postprandial hyperglycemia in adolescents with type 1 diabetes. We studied the effects of exenatide on glucose homeostasis in adults with long-standing type 1 diabetes.Fourteen patients with type 1 diabetes participated in a crossover study of 6 months' duration on exenatide (10 ?g four times a day) and 6 months off exenatide. We assessed changes in fasting and postprandial blood glucose and changes in insulin sensitivity before and after each study period.High-dose exenatide therapy reduced postprandial blood glucose but was associated with higher fasting glucose concentrations without net changes in hemoglobin A1c. Exenatide increased insulin sensitivity beyond the effects expected as a result of weight reduction.Exenatide is a promising adjunctive agent to insulin therapy because of its beneficial effects on postprandial blood glucose and insulin sensitivity in patients with type 1 diabetes.

SUBMITTER: Sarkar G 

PROVIDER: S-EPMC3931382 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes.

Sarkar Gayatri G   Alattar May M   Brown Rebecca J RJ   Quon Michael J MJ   Quon Michael J MJ   Harlan David M DM   Rother Kristina I KI  

Diabetes care 20131105 3


<h4>Objective</h4>Exenatide treatment improves glycemia in adults with type 2 diabetes and has been shown to reduce postprandial hyperglycemia in adolescents with type 1 diabetes. We studied the effects of exenatide on glucose homeostasis in adults with long-standing type 1 diabetes.<h4>Research design and methods</h4>Fourteen patients with type 1 diabetes participated in a crossover study of 6 months' duration on exenatide (10 μg four times a day) and 6 months off exenatide. We assessed changes  ...[more]

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