Unknown

Dataset Information

0

Relations of low contrast visual acuity, quality of life and multiple sclerosis functional composite: a cross-sectional analysis.


ABSTRACT: Although common and often disabling in multiple sclerosis (MS), visual dysfunction is currently not adequately accounted for in both clinical routine and MS trials. Sloan low contrast letter acuity (SLCLA) is a standardised chart-based measure of visual function particular at low contrast and has been suggested as additional visual component to the Multiple Sclerosis Functional Composite (MSFC). Here, we evaluate the relations between SLCLA, retinal integrity, MSFC, and quality of life (QoL) in MS patients.Cross-sectional analysis of retinal nerve fibre layer (RNFL) thickness, MSFC, SLCLA (2.5% and 1.25% contrast levels), visual evoked potentials, and QoL (Short Form (SF) 36, National Eye Institute Visual Functioning Questionnaire (NEIVFQ)) using baseline data of 92 MS patients from an ongoing prospective longitudinal trial. Relations between RNFL thickness or P100 latency and SLCLA were analysed using generalised estimating equations (GEE) accounting for intra-individual inter-eye dependencies and corrected for age, gender, and history of optic neuritis. Pearson's correlations were used to assess relations between SLCLA, MSFC, and QoL.SLCLA reflected RNFL thickness (p?=?0.021) and P100 latency (p?=?0.004) and predicted vision-related QoL, reflected by the NEIVFQ39 subscores "general vision" and "near activities" (p?

SUBMITTER: Schinzel J 

PROVIDER: S-EPMC3932139 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Relations of low contrast visual acuity, quality of life and multiple sclerosis functional composite: a cross-sectional analysis.

Schinzel Johann J   Zimmermann Hanna H   Paul Friedemann F   Ruprecht Klemens K   Hahn Katrin K   Brandt Alexander U AU   Dörr Jan J  

BMC neurology 20140220


<h4>Background</h4>Although common and often disabling in multiple sclerosis (MS), visual dysfunction is currently not adequately accounted for in both clinical routine and MS trials. Sloan low contrast letter acuity (SLCLA) is a standardised chart-based measure of visual function particular at low contrast and has been suggested as additional visual component to the Multiple Sclerosis Functional Composite (MSFC). Here, we evaluate the relations between SLCLA, retinal integrity, MSFC, and qualit  ...[more]

Similar Datasets

| S-EPMC5829587 | biostudies-literature
| S-EPMC5199071 | biostudies-literature
| S-EPMC3964624 | biostudies-literature
| S-EPMC5407511 | biostudies-literature
| S-EPMC5944956 | biostudies-literature
| S-EPMC6863937 | biostudies-literature
| S-EPMC3453526 | biostudies-literature
| S-EPMC3972638 | biostudies-literature
| S-EPMC8762852 | biostudies-literature
| S-EPMC7783398 | biostudies-literature