Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh A
PROVIDER: S-EPMC3932623 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Ghosh Arijit A Haverick Mark M Stump Keith K Yang Xiangyu X Tweedle Michael F MF Goldberger Joshua E JE
Journal of the American Chemical Society 20120213 8
The creation of smart, self-assembling materials that undergo morphological transitions in response to specific physiological environments can allow for the enhanced accumulation of imaging or drug delivery agents based on differences in diffusion kinetics. Here, we have developed a series of self-assembling peptide amphiphile molecules that transform either isolated from molecules or spherical micelles into nanofibers when the pH is slightly reduced from 7.4 to 6.6, in isotonic salt solutions t ...[more]