Ontology highlight
ABSTRACT:
SUBMITTER: Wu K
PROVIDER: S-EPMC3933065 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wu Kongming K Chen Ke K Wang Chenguang C Jiao Xuanmao X Wang Liping L Zhou Jie J Wang Jing J Li Zhiping Z Addya Sankar S Sorensen Poul H PH Lisanti Michael P MP Quong Andrew A Ertel Adam A Pestell Richard G RG
Cancer research 20131212 3
The epithelial-mesenchymal transition (EMT) enhances cellular invasiveness and confers tumor cells with cancer stem cell-like characteristics, through transcriptional and translational mechanisms. The mechanisms maintaining transcriptional and translational repression of EMT and cellular invasion are poorly understood. Herein, the cell fate determination factor Dachshund (DACH1), suppressed EMT via repression of cytoplasmic translational induction of Snail by inactivating the Y box-binding prote ...[more]