Ontology highlight
ABSTRACT:
SUBMITTER: Cozza G
PROVIDER: S-EPMC3933419 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Cozza Giorgio G Zanin Sofia S Determann Renate R Ruzzene Maria M Kunick Conrad C Pinna Lorenzo A LA
PloS one 20140224 2
Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions. SB203580, a p38 MAP kinase inhibitor, has been used as a tool to inhibit HIPK2 in cells, but here we show that its efficacy as HIPK2 inhibitor is negligible (IC₅₀>40 µM). In contrast by altering the scaffold of the promiscuous CK2 inhibitor TBI a new class of HIPK2 inhibit ...[more]